Heart Health: Long-Term Melatonin Use Linked to Cardiovascular Risk

New research indicates that individuals with insomnia who take melatonin supplements for over a year face a higher risk of heart failure compared to those who do not use this common sleep aid. The study reveals that prolonged melatonin use correlates with increased chances of being diagnosed with heart failure, requiring hospitalization, or dying from any cause.

Research Presentation and Status

This research is scheduled to be presented at the American Heart Association’s Scientific Sessions 2025 in New Orleans. It remains a preliminary study and has not yet been published in a peer-reviewed journal.

Study Limitations and Safety Concerns

Researchers emphasize that their findings do not prove a direct cause-and-effect link between melatonin use and heart failure risk. Nevertheless, the results raise concerns about the safety of long-term melatonin supplementation, suggesting a need for more thorough investigation into its cardiovascular impacts.

Regulation and Usage Warnings

Many melatonin supplements are available over-the-counter without prescription, allowing people to use them without medical supervision. These products are not regulated by health authorities, which may pose risks.

“Melatonin supplements may not be as harmless as commonly assumed.”

Author's Summary

Long-term melatonin use may increase heart failure risk, highlighting the need for further research and caution in unsupervised supplementation.

Healthline — 2025-11-05