Hormone Therapy Linked to Autoimmune Disease Risk in Postmenopausal Women
A recent study presented at the annual meeting of the Menopause Society found that hormone therapy (HT) use is associated with an increased incidence and risk for developing autoimmune disease in postmenopausal women.
- Significant increases in risk were linked to menopausal hormone therapy for all autoimmune diseases except Graves disease and hepatitis.
- The study included 889,413 postmenopausal women in both HT and non-HT cohorts after propensity score-matching.
- HT users had a higher incidence of autoimmune disease at five years (6.7% vs 5.3%), at 10 years (8.6% vs 6.7%), and across the postmenopausal period (9.0% vs 7.1%) compared to non-HT users.
According to the study, hormone therapy use is associated with an increased incidence and risk for developing autoimmune disease in postmenopausal women.
Author's summary: Hormone therapy is linked to increased autoimmune disease risk in postmenopausal women.
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Rheumatology Advisor — 2025-10-30