SGLT-2 Inhibitors Tied to Lower Risk for Autoimmune Rheumatic Diseases in Adults With T2D
Research shows that SGLT-2 inhibitors are associated with a reduced risk for autoimmune rheumatic diseases compared to sulfonylureas in adults with type 2 diabetes.
- The study, conducted by Bin Hong and colleagues from Sungkyunkwan University, involved a retrospective cohort of 2,032,157 adults with type 2 diabetes from a South Korean healthcare database.
- After propensity score weighting, the analysis included 1,030,088 SGLT-2 inhibitor initiators and 1,002,069 sulfonylurea initiators.
- The weighted incidence rate was 51.90 and 58.41 per 100,000 person-years for SGLT-2 inhibitors and sulfonylureas, respectively.
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Author's summary: SGLT-2 inhibitors reduce risk.
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Rheumatology Advisor — 2025-10-30