Obesity Gene and Heart Disease
Obesity is often linked to serious health problems like heart disease and high cholesterol.
A new study published in Nature Medicine found that people with a rare genetic condition, MC4R deficiency, might have better heart health than expected despite being obese.
MC4R Deficiency
MC4R stands for melanocortin 4 receptor, a gene that helps control body weight by regulating appetite and energy use.
When this gene doesn’t work properly, it can lead to severe early-onset obesity.
Research Findings
The study found that people with MC4R deficiency had lower cholesterol, lower triglyceride levels, and a lower risk of heart disease.
- Lower cholesterol
- Lower triglyceride levels
- Lower risk of heart disease
The researchers analyzed the genetic data of 7,719 children from the Genetics of Obesity Study (GOOS) and identified 316 children and 144 adult relatives with obesity due to MC4R gene mutations.
People with MC4R deficiency might have better heart health than expected despite being obese.
Author's summary: Obesity gene may prevent heart disease.
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